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Nat Genet. 2016 May 27;48(6):591-2. doi: 10.1038/ng.3579.

DNA-sequence-specific erasers of epigenetic memory.

Author information

1
Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and the Linnean Center for Plant Biology, Uppsala, Sweden.

Abstract

How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatin-modifying complex.

PMID:
27230685
DOI:
10.1038/ng.3579
[Indexed for MEDLINE]

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