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Nat Cell Biol. 2016 May 27;18(6):593-4. doi: 10.1038/ncb3367.

Replicating repetitive DNA.

Author information

1
DNA Replication Group, Institute of Clinical Sciences, Imperial College London, London, W12 0NN, UK.
2
MRC Clinical Sciences Centre, Du Cane Road, London, W12 0NN, UK.
3
Cell Signalling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.

Abstract

The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.

PMID:
27230530
DOI:
10.1038/ncb3367
[Indexed for MEDLINE]
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