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Cell Res. 2016 Jun;26(6):643-4. doi: 10.1038/cr.2016.64. Epub 2016 May 27.

Electrophysiologist shows a cation channel function of MLKL.

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State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.


Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell Research, Xia et al. showed that MLKL functions as a novel class of cation channel.

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