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Pain Physician. 2016 May;19(4):E659-66.

Evaluation of Somatosensory Evoked Potential and Pain Rating Index in a Patient with Spinal Cord Injury Accepted Cell Therapy.

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Department of Cell Therapy, The General Hospital of Chinese People's Armed Police Forces, Beijing.
Department of Electrophysiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, P. R. China.
Department of Cell Therapy, the General Hospital of Chinese People's Armed Police Forces, Beijing.


Spinal cord injury (SCI) causes a high incidence of motor and sensory dysfunctions accompanied with neuropathic pain. No effective treatment is available. Both somatosensory evoked potential (SSEP) and neuropathic pain (NPP) are transmitted via myelinated large diameter fibers of deep sensory pathways. Here we aimed to evaluate whether SSEP can consistently and objectively assess transmission of deep sensory pathways, and to examine the effects of umbilical cord mesenchymal stem cell (UCMSC) transplantation on SSEP and NPP as assessed by the pain rating index (PRI) in a patient with a 2-year history of complete cervical SCI. We demonstrate that SSEP can directly reflect physiological function of myelinated large fibers in deep sensory pathway transmission (NPP is also transmitted by the same pathway). One year after UCMSC transplantation, the SSEP parameter, PRI, and clinical presentations of NPP significantly improved.


Spinal cord, neuropathic pain, somatosensory evoked potential, umbilical cord mesenchymal stem cells.

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