Format

Send to

Choose Destination
Nanoscale. 2016 Jun 9;8(23):11840-50. doi: 10.1039/c6nr02445a.

Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.

Author information

1
Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu.
2
Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu and Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA.
3
Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA and Departamento de Física, Universidad de Sonora, Hermosillo, Sonora, México.
4
Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu and Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
5
Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
6
Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
7
Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
8
Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu and Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu and Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
9
Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA.
10
Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu and Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu and Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA.

Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

PMID:
27228391
DOI:
10.1039/c6nr02445a
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Royal Society of Chemistry
Loading ...
Support Center