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Magn Reson Med. 2016 Aug;76(2):369-79. doi: 10.1002/mrm.26272. Epub 2016 May 26.

Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing.

Author information

1
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA.

Abstract

PURPOSE:

To develop a compressed sensing (CS) acceleration method with a high spectral bandwidth exploiting the spatial-spectral sparsity of MR spectroscopic imaging (MRSI).

METHODS:

Accelerations were achieved using blip gradients during the readout to perform nonoverlapped and stochastically delayed random walks in kx -ky -t space, combined with block-Hankel matrix completion for efficient reconstruction. Both retrospective and prospective CS accelerations were applied to (13) C MRSI experiments, including in vivo rodent brain and liver studies with administrations of hyperpolarized [1-(13) C] pyruvate at 7.0 Tesla (T) and [2-(13) C] dihydroxyacetone at 3.0 T, respectively.

RESULTS:

In retrospective undersampling experiments using in vivo 7.0 T data, the proposed method preserved spectral, spatial, and dynamic fidelities with R(2) ≥ 0.96 and ≥ 0.87 for pyruvate and lactate signals, respectively, 750-Hz spectral separation, and up to 6.6-fold accelerations. In prospective in vivo experiments, with 3.8-fold acceleration, the proposed method exhibited excellent spatial localization of metabolites and peak recovery for pyruvate and lactate at 7.0 T as well as for dihydroxyacetone and its metabolic products with a 4.5-kHz spectral span (140 ppm at 3.0 T).

CONCLUSIONS:

This study demonstrated the feasibility of a new CS approach to accelerate high spectral bandwidth MRSI experiments. Magn Reson Med 76:369-379, 2016. © 2016 Wiley Periodicals, Inc.

KEYWORDS:

Hankel matrix completion; MR spectroscopic imaging; calibrationless parallel imaging; compressed sensing; hyperpolarized carbon-13; random blip gradients

PMID:
27228088
PMCID:
PMC4945498
DOI:
10.1002/mrm.26272
[Indexed for MEDLINE]
Free PMC Article

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