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Temperature (Austin). 2015 Feb 5;2(4):447-8. doi: 10.1080/23328940.2014.996484. eCollection 2015 Oct-Dec.

Reduced oxygen utilization in septic shock: disorder or adaptation?

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Department of Immunology; Institute of Biomedical Sciences; University of São Paulo ; São Paulo, SP Brazil.


A fall in oxygen utilization during septic or endotoxic shock is thought to reflect circulatory hypoxia or mitochondrial dysfunction, but these pathology-oriented hypotheses do not explain all clinical observations. Here we discuss an alternative hypothesis of how oxygen utilization could fall as the result of a physiological thermometabolic adaptation.


LPS; critical care oxygen; fever; hypothermia; hypoxia; metabolism; sepsis; temperature; thermogenesis

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