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Temperature (Austin). 2015 May 26;2(2):178-87. doi: 10.1080/23328940.2015.1040604. eCollection 2015 Apr-Jun.

TRP ion channels in thermosensation, thermoregulation and metabolism.

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Department of Pharmacology; University of Heidelberg ; Heidelberg, Germany.


In humans, the TRP superfamily of cation channels includes 27 related molecules that respond to a remarkable variety of chemical and physical stimuli. While physiological roles for many TRP channels remain unknown, over the past years several have been shown to function as molecular sensors in organisms ranging from yeast to humans. In particular, TRP channels are now known to constitute important components of sensory systems, where they participate in the detection or transduction of osmotic, mechanical, thermal, or chemosensory stimuli. We here summarize our current understanding of the role individual members of this versatile receptor family play in thermosensation and thermoregulation, and also touch upon their immerging role in metabolic control.


BBB, blood-brain barrier; CFO, circumferential organ; DRG, dorsal root ganglion; POA/AH, preoptic area and anterior hypothalamus; TG, trigeminal ganglion; TRP ion channels; TRP, transient receptor potential; Tb, body core temperature; dorsal root ganglion; hypothalamus; nociception; somatosensation; temperature homeostasis; thermoregulation; thermosensation

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