Format

Send to

Choose Destination
Nat Commun. 2016 May 26;7:11725. doi: 10.1038/ncomms11725.

BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.

White AO1,2,3, Kramár EA1,2,3, López AJ1,2,3, Kwapis JL1,2,3,4, Doan J1,2,3, Saldana D1,2,3, Davatolhagh MF5, Alaghband Y1,2,3, Blurton-Jones M1,4,6, Matheos DP1,2,3, Wood MA1,2,3,4.

Author information

1
301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.
2
Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.
3
Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
4
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA.
5
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
6
Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California 92697, USA.

Abstract

Recent evidence implicates epigenetic mechanisms in drug-associated memory processes. However, a possible role for one major epigenetic mechanism, nucleosome remodelling, in drug-associated memories remains largely unexplored. Here we examine mice with genetic manipulations targeting a neuron-specific nucleosome remodelling complex subunit, BAF53b. These mice display deficits in cocaine-associated memory that are more severe in BAF53b transgenic mice compared with BAF53b heterozygous mice. Similar to the memory deficits, theta-induced long-term potentiation (theta-LTP) in the nucleus accumbens (NAc) is significantly impaired in slices taken from BAF53b transgenic mice but not heterozygous mice. Further experiments indicate that theta-LTP in the NAc is dependent on TrkB receptor activation, and that BDNF rescues theta-LTP and cocaine-associated memory deficits in BAF53b transgenic mice. Together, these results suggest a role for BAF53b in NAc neuronal function required for cocaine-associated memories, and also that BDNF/TrkB activation in the NAc may overcome memory and plasticity deficits linked to BAF53b mutations.

PMID:
27226355
PMCID:
PMC4894971
DOI:
10.1038/ncomms11725
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center