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J Infect Dis. 2017 Jan 1;215(1):64-69. doi: 10.1093/infdis/jiw206. Epub 2016 May 25.

Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.

Author information

1
Infectious Diseases Pathology Branch.
2
Médecins Sans Frontières, Barcelona, Spain.
3
Viral Special Pathogens Branch.
4
Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
5
Médecins Sans Frontières.
6
Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology.
7
Ministry of Health, Kinshasa, Democratic Republic of the Congo.

Abstract

Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission.

KEYWORDS:

Bundibugyo virus; Ebola virus disease; Sudan virus; malaria; pathology; placenta; pregnancy

PMID:
27226206
DOI:
10.1093/infdis/jiw206
[Indexed for MEDLINE]
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