Format

Send to

Choose Destination
Sci Rep. 2016 May 26;6:26676. doi: 10.1038/srep26676.

SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development.

Author information

1
Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon 305-701, Korea.
2
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom.
3
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, 463-707, Korea.
4
Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 305-701, Korea.
5
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.
6
Department of Physiology and BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.
7
Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
8
Graduate School of Medical Science and Engineering, KAIST, Daejeon 305-701, Korea.
9
Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, United Kingdom.

Abstract

Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPδ, and PTPσ). These interactions are strongly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic differentiation in contacting axons. In addition, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the interaction of postsynaptic SALM5 with presynaptic LAR-RPTPs. These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength.

PMID:
27225731
PMCID:
PMC4881023
DOI:
10.1038/srep26676
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center