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Lab Chip. 2016 Jun 21;16(12):2188-91. doi: 10.1039/c6lc00479b. Epub 2016 May 26.

Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks.

Author information

1
UMR 168 Physico-Chimie Curie, CNRS, PSL Research University, Institut Curie, 75005, Paris, France. catherine.villard@curie.fr.

Abstract

We present a novel kind of directional axon guides for brain-on-a-chip applications. Contrarily to previous works, the directionality in our design is created by rerouting axons growing in the unwanted direction back to their original compartment while leaving the other growth direction unaffected. This design yields state-of-the-art levels of directionality without the disadvantages of previously reported technologies.

PMID:
27225661
DOI:
10.1039/c6lc00479b
[Indexed for MEDLINE]

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