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ACS Appl Mater Interfaces. 2016 Jun 15;8(23):14442-52. doi: 10.1021/acsami.6b04289. Epub 2016 Jun 3.

Orthogonally Functionalizable Polyurethane with Subsequent Modification with Heparin and Endothelium-Inducing Peptide Aiming for Vascular Reconstruction.

Author information

1
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201620, China.
2
Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai 200127, China.
3
Imaging Diagnosis Center, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine , Shanghai 200127, China.
4
McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania 15219, United States.

Abstract

Surface coimmobilization modifications of blood-contacting devices with both antithrombogenic moieties and endothelium-inducing biomolecules may create a synergistic effect to improve their performance. However, it is difficult to perform covalent dual-functionalization with both biomolecules on the surface of normally used synthetic polymeric substrates. Herein, we developed and characterized an orthogonally functionalizable polymer, biodegradable elastic poly(ester urethane)urea with disulfide and amino groups (PUSN), which was further fabricated into electropun fibrous scaffolds and surface modified with heparin and endothelial progenitor cells (EPC) recruiting peptide (TPS). The modification effects were assessed through platelet adhesion, EPC, and HUVEC proliferation. Results showed the dual modified PUSN scaffolds demonstrated a synergistic effect of reduced platelet deposition and improved EPC proliferation in vitro study, and demonstrated their potential application in small diameter vascular regeneration.

KEYWORDS:

endothelialization; orthogonally functionalizable polymer; polyurethane; surface modification; vascular regeneration

PMID:
27224957
DOI:
10.1021/acsami.6b04289
[Indexed for MEDLINE]

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