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Skin Therapy Lett. 2015 Nov;20(6):6-9.

Tavaborole 5% Solution: A Novel Topical Treatment for Toenail Onychomycosis.

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Wayne State University, Detroit, MI, USA; Mediprobe Research Inc., London, ON, Canada.
Mediprobe Research Inc., London, ON, Canada.
Mediprobe Research Inc., London, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.


Onychomycosis is a stubborn fungal infection of the nails that can be difficult to effectively manage. One of the challenges with topical therapies is penetrating the nail plate to reach the site of infection. As the first antifungal in a boron-containing class of drugs with a novel mechanism of action, tavaborole is able to penetrate the nail plate more effectively than ciclopirox and amorolfine lacquers. In Phase II/III clinical trials, tavaborole was shown to be safe and clinically effective. Tavaborole 5% solution was approved by the US FDA for the treatment of toenail onychomycosis in July 2014 and is an important addition to the topical treatment arsenal against this stubborn infection.

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