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Amyotroph Lateral Scler Frontotemporal Degener. 2016 Oct - Nov;17(7-8):522-527. Epub 2016 May 25.

Amyotrophic lateral sclerosis: A higher than expected incidence in people over 80 years of age.

Author information

1
a Department of Neurology , Vic University Hospital , Vic , Barcelona.
2
b Department of Epidemiology , Vic University Hospital , Vic , Barcelona.
3
c Department of Pharmacy , Vic University Hospital , Vic , Barcelona.
4
d Department of Geriatry , Hospital de la Santa Creu , Vic , Barcelona.
5
e Department of Neurology , Neuromuscular Diseases Unit, Hospital de Bellvitge, Hospitalet de Llobregat , Barcelona.
6
f Department of Neurology , Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona , Barcelona , Spain , and.
7
g Maurice Wohl Clinical Neuroscience Institute, King's College London , Department of Clinical Neuroscience , London , UK.

Abstract

Our objective was to determine the age-specific incidence and clinical-epidemiological characteristics of an amyotrophic lateral sclerosis (ALS) cohort of patients in Catalonia (Spain). New cases diagnosed between 1 January 2004 and 31 December 2013 were 41 (20 males and 21 females), with an annual crude incidence rate of 2.7 per 100,000 person-years (95% CI 1.90-3.59). The incidence rate increased with age reaching a peak in the age group of 70-79 years. There was a non-significant decrease in the incidence rate in the group of patients over 80 years (p-value = 0.75) at 17.99 per 100,000 person years (95% CI 7.81-28.17). The percentage of patients over 80 years of age was 29.3% and over age 85 years was 9.8%. The prevalence rate at the end of the study period was 8.38/100,000 of the total population. Mean age at symptom onset was 76.0 years. Onset of symptoms was bulbar or generalized in 36.6% of cases. In conclusion, ALS incidence in Osona is within the range of other countries across Europe. Our results suggest that the age-specific incidence rate of ALS increases with age through the oldest age groups suggesting an age-risk effect to develop the disease.

PMID:
27224687
DOI:
10.1080/21678421.2016.1187175
[Indexed for MEDLINE]

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