Format

Send to

Choose Destination
See comment in PubMed Commons below
Trop Med Int Health. 2016 Aug;21(8):1013-1018. doi: 10.1111/tmi.12729. Epub 2016 Jun 16.

Predictors of early breastfeeding cessation among HIV-infected women in Botswana.

Author information

  • 1Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
  • 2Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • 3Trinity Medical Centre, Piccadilly, WA, Australia.
  • 4Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
  • 5Brigham and Women's Hospital, Boston, MA, USA.
  • 6Greater Manchester West Mental Health NHS Foundation Trust, Prestwich, UK.
  • 7Goodtables Data Consulting, Norman, OK, USA.
  • 8Beth Israel Deaconess Medical Center, Boston, MA, USA.

Abstract

OBJECTIVE:

Infants born to HIV-infected women receiving antiretroviral treatment (ART) can be breastfed through at least 6 months with very low risk of HIV acquisition. We aimed to identify demographic and cultural factors that may influence mothers' willingness to breastfeed for the recommended duration.

METHODS:

We evaluated factors associated with early cessation of breastfeeding (i.e. before 5 months post-partum) in a randomized clinical trial evaluating different ART regimens used for prevention of mother-to-child transmission during breastfeeding in Botswana. Univariate and multivariable Cox regressions were used to describe predictors of early exclusive BF cessation.

RESULTS:

Among 677 women who started breastfeeding, the median time to breastfeeding cessation was 178 days (IQR 150-181) and 25.1% weaned early. In multivariable analysis, urban location (aHR = 1.86 95%CI 1.27-2.73; P = 0.002), salaried employment or being a student (aHR = 2.78 95% CI 1.63-4.75; P < 0.001) and infant hospitalisation before weaning (aHR = 2.04 95% CI 1.21-3.45; P = 0.008) were independently and significantly associated with early BF cessation.

CONCLUSIONS:

Improved support for breastfeeding among employed mothers, especially in urban settings, may allow HIV-infected women who are receiving ART prophylaxis to breastfeed longer.

KEYWORDS:

HIV ; PMTCT ; PTME ; VIH ; Botswana; allaitement maternel; breastfeeding; lactancia; prevención de la transmisión vertical

PMID:
27224454
PMCID:
PMC4969096
[Available on 2017-08-01]
DOI:
10.1111/tmi.12729
[PubMed - as supplied by publisher]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center