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Genes Dev. 2016 May 15;30(10):1135-7. doi: 10.1101/gad.283598.116.

HOX13 proteins: the molecular switcher in Hoxd bimodal regulation.

Author information

1
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas-Universidad de Cantabria, 39011 Santander, Spain.

Abstract

The striking correlation between the genomic arrangement of Hox genes and their temporal and spatial pattern of expression during embryonic development has been a source of fascination since its discovery. This correspondence has been used as a privileged example in the investigation of the connection between genomic architecture and function. In this issue of Genes & Development, Beccari and colleagues (pp. 1172-1186) make a big step forward in understanding Hox gene regulation during limb development by showing the pivotal role of HOXA13 and HOXD13 proteins in the transition from a proximal to a distal type of Hoxd transcriptional regulation.

KEYWORDS:

ankle; polycomb; regulatory landscapes; topologically associating domains (TADs); vertebrate limbs; wrist

PMID:
27222515
PMCID:
PMC4888835
DOI:
10.1101/gad.283598.116
[Indexed for MEDLINE]
Free PMC Article

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