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Eur Radiol. 2017 Feb;27(2):464-473. doi: 10.1007/s00330-016-4393-4. Epub 2016 May 24.

Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium.

Author information

1
Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline Street, JHOC 5165, Baltimore, MD, 21287, USA.
2
Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
3
Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
4
Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital Sydney, Sydney, Australia.
5
Biomediq, Copenhagen, Denmark.
6
Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD, USA.
7
Division of Rheumatology and Clinical Immunology, University of Arizona, Tucson, AZ, USA.
8
Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline Street, JHOC 5165, Baltimore, MD, 21287, USA. demehri2001@yahoo.com.

Abstract

OBJECTIVES:

Investigating the association between baseline cartilage volume measurements (and initial 24th month volume loss) with medial compartment Joint-Space-Loss (JSL) progression (>0.7 mm) during 24-48th months of study.

METHODS:

Case and control cohorts (Biomarkers Consortium subset from the Osteoarthritis Initiative (OAI)) were defined as participants with (n=297) and without (n=303) medial JSL progression (during 24-48th months). Cartilage volume measurements (baseline and 24th month loss) were obtained at five knee plates (medial-tibial, lateral-tibial, medial-femoral, lateral-femoral and patellar), and standardized values were analysed. Multivariate logistic regression was used with adjustment for known confounders. Artificial-Neural-Network analysis was conducted by Multi-Layer-Perceptrons (MLPs) including baseline determinants, and baseline (1) and interval changes (2) in cartilage volumes.

RESULTS:

Larger baseline lateral-femoral cartilage volume was predictive of medial JSL (OR: 1.29 (1.01-1.64)). Greater initial 24th month lateral-femoral cartilage volume-loss (OR: 0.48 (0.27-0.84)) had protective effect on medial JSL during 24-48th months of study. Baseline and interval changes in lateral-femoral cartilage volume, were the most important estimators for medial JSL progression (importance values: 0.191(0.177-0.204), 0.218(0.207-0.228)) in the ANN analyses.

CONCLUSIONS:

Cartilage volumes (both at baseline and their change during the initial 24 months) in the lateral femoral plate were predictive of medial JSL progression.

KEY POINTS:

• Baseline lateral femoral cartilage volume is directly associated with medial JSL progression. • 24-month lateral femoral cartilage loss is inversely associated with medial JSL progression. • Lateral femoral cartilage volume is most important in association with medial JSL progression.

KEYWORDS:

Cartilage; Knee osteoarthritis; Logistic models; Magnetic resonance imaging; Neural networks

PMID:
27221563
DOI:
10.1007/s00330-016-4393-4
[Indexed for MEDLINE]

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