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Trends Genet. 2016 Jul;32(7):392-394. doi: 10.1016/j.tig.2016.05.002. Epub 2016 May 21.

Fishing for Function in the Human Gene Pool.

Author information

1
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
2
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, California, USA. Electronic address: avisel@lbl.gov.
3
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: dedickel@lbl.gov.

Abstract

Identification and characterization of causal non-coding variants in human genomes is challenging and requires substantial experimental resources. A new study by Tehranchi et al. describes a cost-effective approach for accurate mapping of molecular quantitative trait loci (QTLs) from pooled samples, a powerful way to link disease-associated changes to molecular functions.

KEYWORDS:

GWAS; QTL; cis-regulation; non-coding DNA

PMID:
27220646
PMCID:
PMC4912909
DOI:
10.1016/j.tig.2016.05.002
[Indexed for MEDLINE]
Free PMC Article

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