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Am J Ind Med. 2016 Jul;59(7):509-21. doi: 10.1002/ajim.22598. Epub 2016 May 24.

Synergism between sinusoidal-50 Hz magnetic field and formaldehyde in triggering carcinogenic effects in male Sprague-Dawley rats.

Author information

1
Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
2
Medical University of South Carolina, Chapel Hill, South Carolina.
3
National Institute for Insurance Against Injuries at Work (INAIL), Florence, Italy.

Abstract

BACKGROUND:

Experimental rodent bioassays performed up to now have failed to provide conclusive confirmation of the carcinogenicity of extremely low frequency magnetic fields (ELFMF).

OBJECTIVES:

To evaluate the potential synergistic carcinogenic effects of concurrent exposure to ELFMF and formaldehyde in four groups of male and female Sprague-Dawley rats.

METHODS:

One group was exposed from prenatal life until natural death to S-50 Hz MF and to formaldehyde in drinking water from 6 weeks of age for 104 weeks, two groups were treated only with formaldehyde or only with MF and one group served as untreated control.

RESULTS:

Compared to untreated controls, exposure to MF and formaldehyde causes in males a statistically significant increased incidence of malignant tumors (P ≤ 0.01), thyroid C-cell carcinomas (P ≤ 0.01), and hemolymphoreticular neoplasias (P ≤ 0.05). No statistically significant differences were observed among female groups.

CONCLUSIONS:

Life-span exposure to MF and formaldehyde induces statistically significant carcinogenic effects in male rats. Am. J. Ind. Med. 59:509-521, 2016. © 2016 Wiley Periodicals, Inc.

KEYWORDS:

Sprague-Dawley rats; carcinogenic synergism between S-50 Hz MF plus formaldehyde; hemolymphoreticular neoplasias; life-span bioassays; thyroid C-cell carcinomas

PMID:
27219869
DOI:
10.1002/ajim.22598
[Indexed for MEDLINE]

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