Format

Send to

Choose Destination
Alzheimers Dement. 2017 Jan;13(1):20-27. doi: 10.1016/j.jalz.2016.04.004. Epub 2016 May 21.

The Predictors study: Development and baseline characteristics of the Predictors 3 cohort.

Author information

1
Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. Electronic address: ys11@columbia.edu.
2
Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Abstract

INTRODUCTION:

The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer's disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort.

METHODS:

Patients with prevalent or incident AD and individuals at-risk for developing AD were selected from the North Manhattan community and followed annually with instruments comparable to those used in the original two Predictors cohorts.

RESULTS:

The original Predictors cohorts were clinic based and racially/ethnically homogenous (94% white, 6% black; 3% Hispanic). In contrast, the 274 elders in this cohort are community-based and ethnically diverse (39% white, 40% black, 21% other; 78% Hispanic). Confirming previous observations, psychotic features were associated with poorer function and mental status and extrapyramidal signs with poorer function.

DISCUSSION:

This new cohort will allow us to test observations made in our original clinic-based cohorts in patients that may be more representative of the general community.

KEYWORDS:

ADL; Cognitive function; Extrapyramidal signs; MCI; Pharmacoeconomics; Prediction algorithms; Psychotic features

PMID:
27219818
PMCID:
PMC5118195
DOI:
10.1016/j.jalz.2016.04.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center