Format

Send to

Choose Destination
Br J Cancer. 2016 Jun 28;115(1):85-9. doi: 10.1038/bjc.2016.148. Epub 2016 May 24.

Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink.

Author information

1
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-9774 USA.
2
Boston Collaborative Drug Surveillance Program and Boston University School of Public Health, Lexington, MA, 02421 USA.
3
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-9783, USA.

Abstract

BACKGROUND:

Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.

METHODS:

We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression.

RESULTS:

Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR=1.22, 95% CI=1.03-1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association.

CONCLUSIONS:

Our results do not support a role of antibiotic use in liver cancer development.

PMID:
27219020
PMCID:
PMC4931369
DOI:
10.1038/bjc.2016.148
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center