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Eur J Med Chem. 2016 Sep 14;120:313-28. doi: 10.1016/j.ejmech.2016.05.004. Epub 2016 May 6.

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells.

Author information

1
Departments of Chemistry and Biology, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA.
2
Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, CP205/1, Boulevard du Triomphe, Brussels, Belgium.
3
Service de Neurochirurgie, Hôpital Erasme, ULB, 808 route de Lennik, 1070 Brussels, Belgium.
4
Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA.
5
Dipartimento di Scienze Chimiche, Universita' di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cintia 4, 80126 Napoli, Italy.
6
Greehey Children's Cancer Research Institute, UT Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, USA.
7
Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
8
Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
9
Department of Chemistry, North Caucasus University, 1a Pushkin St., Stavropol 355009, Russian Federation.
10
Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA. Electronic address: a_k76@txstate.edu.
11
Departments of Chemistry and Biology, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA. Electronic address: lfrolova@nmt.edu.

Abstract

Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridine ring system were recently shown to be effective at inhibiting proliferation of cancer cells resistant to various pro-apoptotic stimuli and representing tumors with dismal prognoses refractory to current chemotherapy, such as glioma, melanoma, non-small-cell lung, esophageal, head and neck cancers, among others. Using this discovery as a starting point and taking advantage of a concise biomimetic route to the crinine skeleton, a collection of crinine analogues were synthetically prepared and evaluated against cancer cells. The compounds exhibited single-digit micromolar activities and retained this activity in a variety of drug-resistant cancer cell cultures. This investigation resulted in the discovery of new bicyclic ring systems with significant potential in the development of effective clinical cancer drugs capable of overcoming cancer chemotherapy resistance.

KEYWORDS:

Apoptosis resistance; Glioblastoma; Haemanthamine; Lycorine; Multidrug resistance; Translation inhibition

PMID:
27218860
PMCID:
PMC4943583
DOI:
10.1016/j.ejmech.2016.05.004
[Indexed for MEDLINE]
Free PMC Article

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