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Adv Mater. 2016 Aug;28(32):6860-5. doi: 10.1002/adma.201506407. Epub 2016 May 24.

A Surface-Confined Proton-Driven DNA Pump Using a Dynamic 3D DNA Scaffold.

Author information

1
Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
2
Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.
3
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
4
Chemistry Department, King Saud University, Riyadh, 11451, Saudi Arabia.
5
UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK.

Abstract

A proton-driven molecular pump is devised using a surface-confined dynamic 3D DNA scaffold. A dynamic DNA tetrahedral nanostructure is designed by incorporating a pH-sensitive i-motif sequence in one edge, which serves as the scaffold to ensure highly ordered orientation and spatial isolation of this nanomachine on the macroscopic gold surface. It is found that the switching ability of this dynamic tetrahedron is fully maintained on the surface. Importantly, this proton-driven nanomachine can reversibly pump water and ferricynide in response to pH variation in solution.

KEYWORDS:

DNA nanostructures; dynamic nanodevices; nanopumps; reversible; surface-confined

PMID:
27218679
DOI:
10.1002/adma.201506407
[Indexed for MEDLINE]

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