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Int Forum Allergy Rhinol. 2016 Sep;6(9):943-9. doi: 10.1002/alr.21785. Epub 2016 May 24.

Evaluation of a novel natural drop for treatment of chronic rhinosinusitis without nasal polyps: a single blind randomized trial.

Author information

1
Department of Iranian Traditional Medicine, School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
3
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4
Department of Otolaryngology, Tehran University of Medical Sciences, Tehran, Iran.
5
Clinical Trial Center, Tehran University of Medical Sciences, Tehran, Iran.
6
Department of Biomedical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran.
7
Department of Iranian Traditional Medicine, School of Iranian Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
8
Department of Clinical Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
9
Department of Otolaryngology, Tehran University of Medical Sciences, Tehran, Iran. saedi@tums.ac.ir.

Abstract

BACKGROUND:

The present study investigated the effectiveness of a Pimpinella anisum-based herbal medicine for treating chronic rhinosinusitis (CRS) without polyps in comparison to fluticasone nasal spray, in a single-blinded randomized trial.

METHODS:

Patients with CRS without nasal polyps were randomly assigned into 2 treatment groups: individuals in the first group (n = 26) received 2 drops of a P. anisum-based herbal medicine (Sinupim) in each nostril every 12 hours, while those in the second group (n = 22) received 2 puffs of fluticasone nasal spray in each nostril every 12 hours. Both groups used their designated treatments for 4 weeks. Patients were evaluated by the 22-item Sino-Nasal Outcome Test (SNOT-22) at the start of the trial and after the completion of their treatment.

RESULTS:

Although both treatments were effective in reducing patients' symptoms, there were significantly better results in the Sinupim group based on the SNOT-22 evaluation. Mean changes in computed tomography (CT) scan scoring in Sinupim and fluticasone groups before and after treatment were 2.22 ± 2.94 and 0.76 ± 1.39, respectively, which was significant within both groups (p < 0.05). Postnasal drip and nasal obstruction were more significantly improved in the Sinupim group.

CONCLUSION:

A P. anisum-based herbal medicine may be an effective treatment for sinusitis without polyps. However, its wide acceptance needs further investigation.

KEYWORDS:

Pimpinella anisum; SNOT-22; clinical trial; herbal medicine; sinusitis; treatment

PMID:
27218285
DOI:
10.1002/alr.21785
[Indexed for MEDLINE]

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