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J Clin Endocrinol Metab. 2016 Jul;101(7):2931-6. doi: 10.1210/jc.2016-1177. Epub 2016 May 24.

Decreased Circulating Levels of Spexin in Obese Children.

Author information

1
Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine (S.K., S.S.), Mayo Clinic, Rochester, Minnesota 55905; Biostatistics Core (J.H.), Nemours Biomedical Research, Wilmington, Delaware 19803; Park Nicollet Health Services (N.N.), St Louis, Minnesota 55416; University of Illinois (R.A.), College of Medicine, Peoria, Illinois 61603; and Nemours Children's Specialty Care, Division of Biomedical Research (P.B.B.), Jacksonville, Florida; and Mayo Clinic College of Medicine, Jacksonville, Florida 32207.

Abstract

CONTEXT:

Spexin is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in children.

OBJECTIVE:

The aim of the current study was to determine the potential role of Spexin in obese children and explore its relationships with various cardiometabolic risk factors.

DESIGN AND PARTICIPANTS:

This was a cross-sectional study composed of 69 children (51 obese and 18 normal weight; age 15.3 ± 0.26 y).

OUTCOME MEASURES:

Spexin was measured using a specific enzyme-linked immunosorbent assay. Leptin, total and high-molecular-weight adiponectin, IL-6, high-sensitivity C-reactive protein, glucose, and insulin were also measured. Mann-Whitney U test, Pearson and Spearman rank correlations, logistic regression, and cluster analysis were used for the analysis and interpretation of the data.

RESULTS:

Spexin levels were significantly lower in obese vs normal-weight children, median(IQR) (0.33 ng/mL [0.27-0.44] vs 0.42 ng/mL [0.33-0.55]; P = .024), but did not correlate with other adipokines and/or insulin and glucose levels. Ordinal categorical variables of Spexin showed a strictly reverse association of obesity with the level of Spexin. Cluster analysis of Spexin and body mass index z score resulted in splitting the participants into normal-weight and obese-weight groups with high accuracy.

CONCLUSIONS:

Lower circulating levels of Spexin in obese children compared with their normal-weight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity. The clinical significance of these findings needs additional investigation.

PMID:
27218269
PMCID:
PMC4929838
DOI:
10.1210/jc.2016-1177
[Indexed for MEDLINE]
Free PMC Article
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