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Head Neck. 2016 Dec;38(12):1847-1854. doi: 10.1002/hed.24502. Epub 2016 May 24.

Metastases to nasal cavity and paranasal sinuses.

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Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
University of Oviedo. Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain.
Department of Pathology, Allegiance Health, Jackson, Michigan.
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
University of Udine School of Medicine, Udine, Italy.
Coordinator of the International Head and Neck Scientific Group.


The sinonasal cavities are rare locations for metastases. Metastases to these locations are usually solitary and produce similar symptoms to those of a primary sinonasal tumor. Nasal obstruction and epistaxis are the most frequent symptoms. The maxillary sinus is most frequently involved. The most common primary tumor sites to spread to this region originate in the kidney, breast, thyroid, and prostate, although any malignancy could potentially lead to a metastasis to the paranasal sinuses. The patient's prognosis is usually poor because of the fact that the sinonasal metastasis is usually associated with widespread disseminated disease. In the majority of patients, palliative therapy is the only possible treatment option. Nevertheless, whenever possible, surgical excision either alone or combined with radiotherapy may be useful for palliation of symptoms and, rarely, to achieve prolonged survival. This review considers the most interesting cases reported in the literature that presents metastases to the sinonasal cavities.


maxillary sinus; metastases; nasal cavity; paranasal sinuses; sinonasal cavities

[Indexed for MEDLINE]

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