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Ann Oncol. 2016 Jul;27(7):1329-36. doi: 10.1093/annonc/mdw172. Epub 2016 May 23.

Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis.

Author information

1
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA Institution of Hematology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, USA.
3
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA.
4
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong, University School of Medicine, Shanghai, China.
5
International Epidemiology Institute, Rockville.
6
Department of Internal Medicine, Meharry Medical College, Nashville, USA.
7
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA International Epidemiology Institute, Rockville.
8
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA xiao-ou.shu@vanderbilt.edu.

Abstract

BACKGROUND:

While studies have shown that poor oral health status may increase the risk of cancer, evidence of a specific association with the risk of colorectal cancer (CRC) is inconclusive. We evaluated the association between oral health and CRC risk using data from three large cohorts: the Shanghai Men's Health Study (SMHS), the Shanghai Women's Health Study (SWHS), and the Southern Community Cohort Study (SCCS), and carried out a meta-analysis of results from other relevant published studies.

PATIENTS AND METHODS:

This study applied a nested case-control study design and included 825 cases/3298 controls from the SMHS/SWHS and 238 cases/2258 controls from the SCCS. The association between oral health status (i.e. tooth loss/tooth decay) and CRC risk was assessed using conditional logistic regression models. A meta-analysis was carried out based on results from the present study and three published studies.

RESULTS:

We found that tooth loss was not associated with increased risk of CRC. ORs and respective 95% CIs associated with loss of 1-5, 6-10, and >10 teeth compared with those with full teeth are 0.87 (0.69-1.10), 0.93 (0.70-1.24), and 0.85 (0.66-1.11) among SMHS/SWHS participants; and 1.13 (0.72-1.79), 0.87 (0.52-1.43), and 1.00 (0.63-1.58) for those with loss of 1-4, 5-10, and >10 teeth among SCCS participants. Data regarding tooth decay were available in the SCCS, but were not associated with CRC risk. Meta-analysis confirmed the null association between tooth loss/periodontal disease and CRC risk (OR 1.05, 95% CI 0.86-1.29).

CONCLUSION:

In this analysis of three cohorts and a meta-analysis, we found no evidence supporting an association between oral health and CRC risk.

KEYWORDS:

colorectal cancer risk; oral health; periodontal disease; tooth decay; tooth loss

PMID:
27217540
PMCID:
PMC4922320
DOI:
10.1093/annonc/mdw172
[Indexed for MEDLINE]
Free PMC Article

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