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Antimicrob Agents Chemother. 2016 May 23;60(6):3270-5. doi: 10.1128/AAC.03118-15. Print 2016 Jun.

An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase.

Author information

1
Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
2
Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
3
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
4
Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA.
5
Seattle Children's Research Institute, Seattle, Washington, USA.
6
Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
7
Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA banerjee.ritu@mayo.edu Kkaye@dmc.org.
8
Wayne State University and Detroit Medical Center, Detroit, Michigan, USA.
9
Wayne State University and Detroit Medical Center, Detroit, Michigan, USA banerjee.ritu@mayo.edu Kkaye@dmc.org.

Abstract

We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was blaNDM positive, the other demonstrated meropenem susceptibility yet harbored blaOXA181 (which encodes a blaOXA48-like enzyme). This report highlights the challenge of laboratory detection of blaOXA48-like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae.

PMID:
27217442
PMCID:
PMC4879384
DOI:
10.1128/AAC.03118-15
[Indexed for MEDLINE]
Free PMC Article

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