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Antimicrob Agents Chemother. 2016 Jul 22;60(8):5033-5. doi: 10.1128/AAC.00440-16. Print 2016 Aug.

Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.

Author information

1
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
2
The Center of Clinical Diagnosis Laboratory, 302 Hospital of PLA, Beijing, China.
3
Department of Laboratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
4
Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
5
Center of Medical Laboratory, the General Hospital of Ningxia Medical University, Yinchuan, China.
6
Department of Laboratory Medicine, The Traditional Chinese Medical Hospital of Guangdong, Guangzhou, Guangdong, China.
7
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
8
Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
9
Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
10
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China hong_du@126.com Chen11@njms.rutgers.edu.
11
Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA hong_du@126.com Chen11@njms.rutgers.edu.

Abstract

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

PMID:
27216058
PMCID:
PMC4958199
DOI:
10.1128/AAC.00440-16
[Indexed for MEDLINE]
Free PMC Article

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