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Clin Exp Rheumatol. 2016 Jul-Aug;34(4):690-3. Epub 2016 May 19.

Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome.

Author information

1
Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway. opalm@ous-hf.no.
2
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.
3
Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
4
Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; Institute of Clinical Medicine, University of Oslo; and Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Norway.
5
Department of Radiology and Nuclear Medicine, Oslo University Hospital Rikshospitalet, Norway.
6
Department of Rheumatology, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.

Abstract

OBJECTIVES:

To investigate serum levels of endostatin in a well characterised cohort of patients with primary Sjögren's syndrome (pSS) and healthy controls (HC) and assess associations between these mediators and clinical parameters.

METHODS:

All patients (n=144) were recruited from the Norwegian systemic connective tissue disease and vasculitis registry (NOSVAR) and fulfilled American-European classification criteria for pSS. Pulmonary involvement was based on clinical symptoms and abnormal findings on high-resolution computed tomography of the lungs. The controls were 100 healthy blood donors. Serum levels of endostatin was determined by enzyme immunoassay.

RESULTS:

We found higher mean levels of serum endostatin in patients with pSS compared with the controls (p<0.001). The patients with interstitial lung disease (ILD) had higher levels compared with those without pulmonary involvement.

CONCLUSIONS:

Our results indicate that endostatin is increased in patients with pSS and particularly in those with ILD.

PMID:
27214260
[Indexed for MEDLINE]

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