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Nat Commun. 2016 May 23;7:11650. doi: 10.1038/ncomms11650.

A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring.

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1
Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California 92093-0407, USA.
2
Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093-0448, USA.

Abstract

Flexible, wearable sensing devices can yield important information about the underlying physiology of a human subject for applications in real-time health and fitness monitoring. Despite significant progress in the fabrication of flexible biosensors that naturally comply with the epidermis, most designs measure only a small number of physical or electrophysiological parameters, and neglect the rich chemical information available from biomarkers. Here, we introduce a skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram), for more comprehensive fitness monitoring than from physical or electrophysiological sensors alone. The two sensing modalities, comprising a three-electrode amperometric lactate biosensor and a bipolar electrocardiogram sensor, are co-fabricated on a flexible substrate and mounted on the skin. Human experiments reveal that physiochemistry and electrophysiology can be measured simultaneously with negligible cross-talk, enabling a new class of hybrid sensing devices.

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