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Genomics Proteomics Bioinformatics. 2016 Jun;14(3):140-6. doi: 10.1016/j.gpb.2016.04.001. Epub 2016 May 20.

UFMylation: A Unique & Fashionable Modification for Life.

Author information

  • 1Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing 100048, China.
  • 2Beijing Key Laboratory of DNA Damage Response and College of Life Sciences, Capital Normal University, Beijing 100048, China. Electronic address: Xingzhi_Xu@mail.cnu.edu.cn.

Abstract

Ubiquitin-fold modifier 1 (UFM1) is one of the newly-identified ubiquitin-like proteins. Similar to ubiquitin, UFM1 is conjugated to its target proteins by a three-step enzymatic reaction. The UFM1-activating enzyme, ubiquitin-like modifier-activating enzyme 5 (UBA5), serves as the E1 to activate UFM1; UFM1-conjugating enzyme 1 (UFC1) acts as the E2 to transfer the activated UFM1 to the active site of the E2; and the UFM1-specific ligase 1 (UFL1) acts as the E3 to recognize its substrate, transfer, and ligate the UFM1 from E2 to the substrate. This process is called ufmylation. UFM1 chains can be cleaved from its target proteins by UFM1-specific proteases (UfSPs), suggesting that the ufmylation modification is reversible. UFM1 cascade is conserved among nearly all of the eukaryotic organisms, but not in yeast, and associated with several cellular activities including the endoplasmic reticulum stress response and hematopoiesis. Furthermore, the UFM1 cascade is closely related to a series of human diseases. In this review, we summarize the molecular details of this reversible modification process, the recent progress of its functional studies, as well as its implication in tumorigenesis and potential therapeutic targets for cancer.

KEYWORDS:

Cancer; Endoplasmic reticulum stress; Post-translation modification; Ubiquitin-fold modifier 1; Ubiquitin-like proteins; Ufmylation

PMID:
27212118
PMCID:
PMC4936604
DOI:
10.1016/j.gpb.2016.04.001
[PubMed - in process]
Free PMC Article

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