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J Clin Immunol. 2016 May;36 Suppl 1:57-67. doi: 10.1007/s10875-016-0294-1. Epub 2016 May 23.

Autoimmunity and Primary Immunodeficiency Disorders.

Author information

1
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
2
Seattle Children's Research Institute, 1900 9th Ave., JMB-7, Seattle, WA, 98101-1304, USA.
3
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA. troy.torgerson@seattlechildrens.org.
4
Seattle Children's Research Institute, 1900 9th Ave., JMB-7, Seattle, WA, 98101-1304, USA. troy.torgerson@seattlechildrens.org.

Abstract

Advances in DNA sequencing technologies have led to a quickening in the pace at which new genetic immunodeficiency disorders have been identified. Among the newly identified defects are a number of disorders that present primarily with autoimmunity as opposed to recurrent infections. These "immune dysregulation" disorders have begun to cluster together to form an increased understanding of some of the basic molecular mechanisms that underlie the establishment and maintenance of immune tolerance and the development of autoimmunity. This review will present three major themes that have emerged in our understanding of the mechanisms that underlie autoimmunity and immune dysregulation in humans.

KEYWORDS:

CTLA4—cytotoxic T lymphocyte-associated protein 4; CVID—common variable immune deficiency; IL-10—interleukin-10; IPEX—immune dysregulation, polyendocrinopathy, enteropathy, X-linked; NF-κB—nuclear factor-kappa binding; PIDD—primary immunodeficiency disorders; STAT—signal transducer and activator of transcription; Treg—regulatory T cell

PMID:
27210535
DOI:
10.1007/s10875-016-0294-1
[Indexed for MEDLINE]

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