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Carcinogenesis. 1989 Jun;10(6):1085-7.

Structure of a mutagen from roasted seeds of Moringa oleifera.

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  • 1Institute of Chemistry, University of the Philipines, Diliman, Quezon City.


A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(alpha-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(alpha-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound.

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