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Infect Dis Clin North Am. 2016 Jun;30(2):391-414. doi: 10.1016/j.idc.2016.02.005.

Agents of Last Resort: Polymyxin Resistance.

Author information

1
Division of Infectious Diseases, Department of Medicine, Detroit Medical Center, Wayne State University, 3990 John R, Detroit, MI 48201, USA. Electronic address: kkaye@dmc.org.
2
Department of Pharmacy Services, Sinai-Grace Hospital, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI, USA.
3
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

Abstract

Polymyxin resistance is a major public health threat, as the polymyxins represent "last-line" therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

KEYWORDS:

Colistin; Gram-negative; Polymyxin B; Polymyxins; Resistance

PMID:
27208765
DOI:
10.1016/j.idc.2016.02.005
[Indexed for MEDLINE]

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