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Methods. 2016 Sep 1;107:42-7. doi: 10.1016/j.ymeth.2016.05.011. Epub 2016 May 18.

Identification of human RNA editing sites: A historical perspective.

Author information

1
Department of Genetics, Stanford University, Stanford, CA 94305, USA; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: GRamaswami@mednet.ucla.edu.
2
Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: jin.billy.li@stanford.edu.

Abstract

A-to-I RNA editing is an essential gene regulatory mechanism. Once thought to be a rare phenomenon only occurring in a few transcripts, the emergence of high-throughput RNA sequencing has facilitated the identification of over 2 million RNA editing sites in the human transcriptome. In this review, we survey the current RNA-seq based methods as well as historical methods used to identify RNA editing sites.

KEYWORDS:

Post-transcriptional gene regulation; RNA editing; RNA sequencing

PMID:
27208508
PMCID:
PMC5014717
DOI:
10.1016/j.ymeth.2016.05.011
[Indexed for MEDLINE]
Free PMC Article

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