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Thromb Res. 2016 May;141 Suppl 2:S68-72. doi: 10.1016/S0049-3848(16)30370-X.

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

Author information

1
Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address: khoffmeister@bwh.harvard.edu.
2
Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.

Abstract

The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor.

KEYWORDS:

Ashwell Morell Receptor; JAK2; STAT3; glycans; platelet clearance; thrombopoietin

PMID:
27207430
PMCID:
PMC5399515
DOI:
10.1016/S0049-3848(16)30370-X
[Indexed for MEDLINE]
Free PMC Article

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