Format

Send to

Choose Destination
Prog Transplant. 2016 Jun;26(2):172-7. doi: 10.1177/1526924816640978. Epub 2016 Apr 6.

Delayed Graft Function in Kidney Transplantation: Risk Factors and Impact on Early Graft Function.

Author information

1
Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey.
2
Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey drismailsertege@yahoo.com.
3
Tepecik Training and Research Hospital, Department of Nephrology, Izmir, Turkey.
4
Tepecik Training and Research Hospital, Department of Pediatric Nephrology, Izmir, Turkey.
5
Katip Celebi University, School of Medicine, Department of Medical Biology, Izmir, Turkey Tepecik Training and Research Hospital, Department of Immunology, Izmir, Turkey.

Abstract

CONTEXT:

Although kidney transplantations are routinely performed at many centers in Turkey, the incidence and risk factors associated with delayed graft function (DGF) here have not yet been well defined.

OBJECTIVE:

The aim of this study is to evaluate the incidence and risk factors of DGF and its impact on early graft function.

DESIGN:

The medical charts of 154 adult patients who underwent deceased donor kidney transplantation between 2000 and 2014 in a single center were reviewed retrospectively.

SETTING:

Delayed graft function-related risk factors for donors, recipients, and the transplant surgery itself were analyzed, and their relation with graft function was evaluated.

MAIN OUTCOMES MEASURES:

The median recipient age was 39 years. The median cold ischemia time (CIT) was 840 minutes (14 hours). The incidence of DGF and acute rejection were 57.8% and 8.4%, respectively. Higher serum creatinine levels at 3, 6, and 12 months were observed in patients with DGF compared to other patients without DGF (P < .05). Patients with DGF had poor graft function (glomerular filtration rate ≤ 50) at 3 and 6 months (P < .05), but these correlations were not seen at 12 months (P = not significant).

RESULTS:

This study showed that DGF was a common and serious problem associated with poor graft functions at 3, 6, and 12 months after transplantation. Extra effort to shorten CIT as an independent risk factor for DGF could have protective effect on graft functions.

KEYWORDS:

cold ischemia time; delayed graft function; glomerular filtration rate; graft function; incidence; risk factors; serum creatinine

PMID:
27207406
DOI:
10.1177/1526924816640978
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center