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Cell. 2016 May 19;165(5):1055-1066. doi: 10.1016/j.cell.2016.05.004.

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: wu@crystal.harvard.edu.
2
MTA-DE Momentum, Laboratory of Protein Dynamics, Department of Biochemistry and Molecular Biology, University of Debrecen, 4010 Debrecen, Hungary. Electronic address: fmoni@med.unideb.hu.

Abstract

We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the formation and intrinsic fuzziness of all higher-order assemblies, creating a structural and dynamic continuum. We describe how such regulatory mechanisms could be influenced under pathological conditions.

PMID:
27203110
PMCID:
PMC4878688
DOI:
10.1016/j.cell.2016.05.004
[Indexed for MEDLINE]
Free PMC Article

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