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Clin Infect Dis. 2016 Aug 15;63(4):565-8. doi: 10.1093/cid/ciw330. Epub 2016 May 19.

Implementation of Molecular Surveillance After a Cluster of Fatal Toxoplasmosis at 2 Neighboring Transplant Centers.

Author information

1
Infectious Diseases Department of Medicine.
2
Department of Infectious Disease Service.
3
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College.
4
Department of Clinical Laboratories, Memorial Sloan Kettering Cancer Center, New York, New York.
5
Bone Marrow Transplant Service Department of Medicine.
6
Department of Medicine Department of Bone Marrow Transplant Service Department of Medicine.
7
Department of Medicine Department of Infection Control Department of Infectious Disease Service Department of Medicine.
8
Department of Medicine Department of Infectious Disease Service Department of Medicine.

Abstract

After a cluster of fatal toxoplasmosis among stem cell transplant recipients at 2 hospitals, surveillance with polymerase chain reaction (PCR) (blood) was instituted. Rate of reactivation among seropositive recipients was 2.2 and 16%. Parasitemia was successfully managed with preemptive treatment. For seropositive recipients unable to take prophylaxis, toxoplasma PCR surveillance should be routinely performed.

KEYWORDS:

CD34+ selected; T-cell depleted; reactivation; stem cell transplant; toxoplasmosis

PMID:
27199460
PMCID:
PMC4967604
DOI:
10.1093/cid/ciw330
[Indexed for MEDLINE]
Free PMC Article

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