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Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H168-76. doi: 10.1152/ajpheart.00132.2016. Epub 2016 May 6.

The endothelial glycocalyx promotes homogenous blood flow distribution within the microvasculature.

Author information

1
Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Medicine, Denver Veterans Affairs Medical Center, Denver, Colorado; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado;
2
Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, Aurora, Colorado; and.
3
Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Medicine, Denver Veterans Affairs Medical Center, Denver, Colorado; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Center for Women's Health Research, University of Colorado School of Medicine, Aurora, Colorado jane.reusch@ucdenver.edu.

Abstract

Many common diseases involve impaired tissue perfusion, and heterogeneous distribution of blood flow in the microvasculature contributes to this pathology. The physiological mechanisms regulating homogeneity/heterogeneity of microvascular perfusion are presently unknown. Using established empirical formulations for blood viscosity modeling in vivo (blood vessels) and in vitro (glass tubes), we showed that the in vivo formulation predicts more homogenous perfusion of microvascular networks at the arteriolar and capillary levels. Next, we showed that the more homogeneous blood flow under simulated in vivo conditions can be explained by changes in red blood cell interactions with the vessel wall. Finally, we demonstrated that the presence of a space-filling, semipermeable layer (such as the endothelial glycocalyx) at the vessel wall can account for the changes of red blood cell interactions with the vessel wall that promote homogenous microvascular perfusion. Collectively, our results indicate that the mechanical properties of the endothelial glycocalyx promote homogeneous microvascular perfusion. Preservation or restoration of normal glycocalyx properties may be a viable strategy for improving tissue perfusion in a variety of diseases.

KEYWORDS:

glycocalyx; microvascular perfusion; oxygen delivery; perfusion heterogeneity

PMID:
27199117
PMCID:
PMC6189750
DOI:
10.1152/ajpheart.00132.2016
[Indexed for MEDLINE]
Free PMC Article

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