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Biochem Biophys Res Commun. 1989 Apr 28;160(2):828-33.

Steroid induced exocytosis: the human sperm acrosome reaction.

Author information

1
Department of Human Anatomy, University of California, Davis 95616.

Abstract

By a combination of organic precipitation and high pressure liquid chromatography, human sperm acrosome reaction inducing activity has been purified from the fluid aspirated from preovulatory human ovarian follicles and identified as 4-pregnen-3,20-dione (progesterone) and 4-pregnen-17 alpha-ol-3,20-dione (17 alpha-hydroxyprogesterone). It is argued that progesterone is present at the site of fertilization of placental mammals in concentrations sufficient for activity, and hence provides a mechanism of inducing the acrosome reaction, an exocytotic event, in vivo.

PMID:
2719699
DOI:
10.1016/0006-291x(89)92508-4
[Indexed for MEDLINE]

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