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Cell Death Dis. 2016 May 19;7:e2226. doi: 10.1038/cddis.2016.132.

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer.

Author information

1
Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
2
Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
3
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Abstract

Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential targets for novel and specific cancer therapies. Among these targets, the carnitine palmitoyltransferase system is responsible for delivering the long-chain fatty acid (FA) from cytoplasm into mitochondria for oxidation, where carnitine palmitoyltransferase I (CPTI) catalyzes the rate-limiting step of fatty acid oxidation (FAO). With increasing understanding of the crucial role had by fatty acid oxidation in cancer, CPTI has received renewed attention as a pivotal mediator in cancer metabolic mechanism. CPTI activates FAO and fuels cancer growth via ATP and NADPH production, constituting an essential part of cancer metabolism adaptation. Moreover, CPTI also functionally intertwines with other key pathways and factors to regulate gene expression and apoptosis of cancer cell. Here, we summarize recent findings and update the current understanding of FAO and CPTI in cancer and provide theoretical basis for this enzyme as an emerging potential molecular target in cancer therapeutic intervention.

PMID:
27195673
PMCID:
PMC4917665
DOI:
10.1038/cddis.2016.132
[Indexed for MEDLINE]
Free PMC Article

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