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Brain Tumor Res Treat. 2016 Apr;4(1):21-5. doi: 10.14791/btrt.2016.4.1.21. Epub 2016 Apr 29.

A Case of Nongerminomatous Germ Cell Tumor with Fulminant Course Concomitant Leptomeningeal Metastasis.

Author information

1
Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
2
Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.; Department of Anatomy, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
3
Division of Pediatric Radiology, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.
4
Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.; Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
5
Department of Radiation Oncology, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Abstract

We present the case of a 9-year-old boy with a non-germinomatous germ cell tumor (NGGCT) in the pineal gland that exhibited a fulminant course following chemo- and radiotherapy. After the detection of the tiny cerebellar enhancing nodule at the end of chemo- and radiotherapy, tumor seeding progressed rapidly into the entire cisternal space. We herein report a rare case of NGGCT with fulminant clinical course of concomitant cerebellar seeding, with review of literature.

KEYWORDS:

Cerebellar neoplasm; Cerebrospinal fluid; Germ cell tumor; Neoplasm metastasis; Pinealoma; Tumor markers

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