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Iran Red Crescent Med J. 2016 Feb 28;18(2):e34559. doi: 10.5812/ircmj.34559. eCollection 2016 Feb.

Comparing Gabapentin and Celecoxib in Pain Management and Complications After Laminectomy: A Randomized Double-Blind Clinical Trial.

Author information

1
Department of Anaesthesiology, Medicine Faculty, Ilam University of Medical Sciences, Ilam, IR Iran.
2
Department of Nursing, Nursing and Midwifery Faculty, Ilam University of Medical Sciences, Ilam, IR Iran.
3
Department of Midwifery, Nursing and Midwifery Faculty, Ilam University of Medical Sciences, Ilam, IR Iran.

Abstract

BACKGROUND:

Complications and postoperative pain are major care problems that can affect the quality of health care plan.

OBJECTIVES:

According to the use of multimodal therapy the current study aimed to compare the efficacy of gabapentin and celecoxib in pain management and complications after laminectomy at Ilam University of Medical Sciences, Ilam, Iran, in 2015.

PATIENTS AND METHODS:

In this randomized double-blind clinical trial, 114 patients scheduled for elective laminectomy with simple random sampling design received gabapentin (n = 38, 900 mg/day), celecoxib (n = 38, 600 mg/day) and placebo (n = 38, capsule contain starch). Visual analog scale (VAS) was used to determine the intensity of pain. Complications after surgery, anxiety scores before surgery and patient's satisfaction 24 hours after the surgery were recorded.

RESULTS:

The mean pain intensity in the gabapentin group was lower compared to those of the placebo and celecoxib groups respectively at different time durations (P < 0.001). The means of morphine consumption were 11.9 mg, 22.8 mg and 30.1 mg in the gabapentin, celecoxib and placebo groups, respectively (P < 0.001). The prevalence of shivering, nausea, vomiting and pruritus were 10.5%, 12.8%, 10.3% and 18.4% in the gabapentin group vs 31.5%, 29.8%, 32.4% and 28.9% in the celecoxib group and 42.1%, 44.7%, 39.5% and 44.7% in the placebo group (P < 0.001). The mean anxiety score in the gabapentin group was 2.4 vs those of the celecoxib group 3 and placebo group 3.6 (P < 0.001). The frequencies of drowsiness were 42.1%, 13.2% and 5.3% in the gabapentin, celecoxib and placebo groups, respectively (P < 0.001). In the gabapentin group, patient satisfaction was significantly higher compared to those of the placebo and celecoxib groups (P < 0.05).

CONCLUSIONS:

According to the effect of gabapentin on pain management, complications after laminectomy and increased patients satisfaction, it can be regarded as an alter native in multimodal analgesia.

KEYWORDS:

Analgesia; Celecoxib; Gabapentin; Laminectomy; Multimodal Therapy

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