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Dermatoendocrinol. 2016 Apr 19;8(1):e1079359. doi: 10.1080/19381980.2015.1079359. eCollection 2016 Jan-Dec.

Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol.

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Gynecologist, Endocrinology, Oncology, Umweltmedizinisches Therapiezentrum am Dom , München, Germany.
Arzt und Apotheker, Klösterl-Apotheke , München, Germany.
Ordinarius, Dep. Gynecology and Obstetrics, Int. University of Oradea , Oradea, Romania.
Ordinarius, Dep. Urology, Int. University of Oradea , Oradea, Romania.


After the age of 55 almost every third woman suffers from conditions of the incapability to retain urine when the intra-abdominal pressure is raised by different causes. So called stress incontinence. It' s caused by a predisposition in the family, weakness of the tissue, physical strain, deficiency in the metabolism, especially an increasing local estrogen deficiency and a local and systemic vitamin D deficiency.


We evaluated the data of 60 meno- and postmenopausal female patients with a stress incontinence (SIC). All had a SIC in spite of a former local estriol treatment with a treatment of OeKolp® forte (= 0.5 mg estriol/ov), 3 times a week, for 6 weeks and in spite of a regular pelvic floor exercise for 6 weeks in the morning and in the evening, according to the protocol. Thirty were in stage I SIC and 30 were in stage II SIC.


We evaluated vitamin-D-levels in serum of our 60 postmenopausal women. Only 20% of this group had good vitamin D-levels. The medical intervention combined estriol (0.5 mg) together with high dosed vitamin D (12.500 I.U.) locally 3 times a week for a period of 6 weeks. The patients also had the instruction to continue their daily exercises in pelvic floor (morning and evening, due to their protocol). After six weeks of treatment the vitamin D level in serum was defined and correlated to the patients condition (symptomatic of stress incontinence, protocol of micturitions, Pad-test).


About one-third of women from our test assigned to be now capable of retaining urine. More than one-third of our patients cleared a profit of treatment. They reported mimimum regression about 25% of volume of incontinence. Therefore more than 2-third of our women being incapable of retaining urine improved their body conditions by using a combination of locally administered etriol and high dosed vitamin D.


Stress incontinence (being incapable of retaining urine when the intra-abdominal pressure arises) in lower and middle grade, improves their body conditions under a combination of local administered estriol and vitamin D. This small study is not representative. We need much bigger studies with much more dates and with a follow up.


SIC; cholecalciferol; estriol; high dosed vaginal vitamin D; pelvic floor weakness; stress incontinence; vitamin D

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