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J Neural Transm (Vienna). 2016 Oct;123(10):1213-7. doi: 10.1007/s00702-016-1574-x. Epub 2016 May 19.

Effects of theta-rhythm transcranial alternating current stimulation (4.5 Hz-tACS) in patients with clozapine-resistant negative symptoms of schizophrenia: a case series.

Author information

1
Résidence ENNESRINE, Cab G12, 2036, La Soukra, Tunisia.
2
Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale, Medical School, Université Laval, Québec, QC, Canada.
3
Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale, Medical School, Université Laval, Québec, QC, Canada. jerome.brunelin@ch-le-vinatier.fr.
4
INSERM U1028, CNRS UMR5292, Lyon University, University Lyon 1, Lyon Neuroscience Research Center, PSYR2 team: Psychiatric Disorders: from Resistance to Response Team, Centre Hospitalier Le Vinatier, 69678, Bron, France. jerome.brunelin@ch-le-vinatier.fr.

Abstract

Our aim was to assess the efficacy and safety of theta-rhythm transcranial Alternating Current Stimulation (4.5 Hz-tACS) in patients with clozapine-resistant symptoms of schizophrenia. In an open case series, 3 patients received 20 sessions of 4.5 Hz-tACS (20 min, 2 mA) applied over the dorsolateral prefrontal cortex. The patients exhibited a decrease of negative symptoms (-10 %), general symptoms (-18 %) and an improvement of insight into the illness (-25 %). 4.5 Hz-tACS might be a suitable alternative treatment for clozapine-resistant symptoms of schizophrenia.

KEYWORDS:

DLPFC; Insight; Prefrontal cortex; Schizophrenia; tACS; tDCS

PMID:
27194229
DOI:
10.1007/s00702-016-1574-x
[Indexed for MEDLINE]

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