Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2016 Jun 27;55(27):7655-9. doi: 10.1002/anie.201510938. Epub 2016 May 19.

CLIP-COSY: A Clean In-Phase Experiment for the Rapid Acquisition of COSY-type Correlations.

Author information

1
Institut für Organische Chemie and Institut für Biologische, Grenzflächen 4-Magnetische Resonanz, Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
2
Institut für Organische Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, Germany.
3
Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Alarich-Weiss-Strasse 16, 64287, Darmstadt, Germany.
4
Institut für Organische Chemie and Institut für Biologische, Grenzflächen 4-Magnetische Resonanz, Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany. Burkhard.Luy@kit.edu.

Abstract

The COSY experiment is an essential homonuclear 2D NMR experiment for the assignment of resonances. Its multiplet line shape, however, is often overly complicated, potentially leads to signal intensity losses, and is responsible for long minimum overall acquisition times. Herein, we present CLIP-COSY, a COSY-type experiment yielding clean in-phase peaks. It can be recorded within a few minutes and benefits from enhanced signal intensities for most cross-peaks. In combination with non-uniform sampling, the experiment times can be further reduced, and the in-phase multiplets enable the application of modern homonuclear decoupling techniques in both dimensions. As antiphase cancelations are avoided, CLIP-COSY can also be applied to macromolecules and other samples with broadened lines.

KEYWORDS:

COSY; NMR spectroscopy; analytical methods; perfect echo; rapid acquisition

PMID:
27194222
DOI:
10.1002/anie.201510938

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center