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Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9). pii: a019505. doi: 10.1101/cshperspect.a019505.

Epigenetic Determinants of Cancer.

Author information

1
Cancer Biology Program, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287.
2
Van Andel Research Institute, Grand Rapids, Michigan 49503.

Abstract

SUMMARYEpigenetic changes are present in all human cancers and are now known to cooperate with genetic alterations to drive the cancer phenotype. These changes involve DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin. Cancer genetics and epigenetics are inextricably linked in generating the malignant phenotype; epigenetic changes can cause mutations in genes, and, conversely, mutations are frequently observed in genes that modify the epigenome. Epigenetic therapies, in which the goal is to reverse these changes, are now one standard of care for a preleukemic disorder and form of lymphoma. The application of epigenetic therapies in the treatment of solid tumors is also emerging as a viable therapeutic route.

PMID:
27194046
PMCID:
PMC5008069
DOI:
10.1101/cshperspect.a019505
[Indexed for MEDLINE]
Free PMC Article

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